Metal-catalysed auto-oxidation of isoniazid.

نویسندگان

  • F G WINDER
  • J M DENNENY
چکیده

Isoniazid (isonicotinic acid hydrazide) is stable in the solid state and in concentrated aqueous solutions. In dilute aqueous solutions, however, it breaks down under certain conditions. This breakdown has been shown to require oxygen (and hence may be described as an auto-oxidation) and certain metal ions, either free, such as Mn2+, Cu2+, Fe"+, or combined as haemin; and to be accelerated by increase of pH (Pansy, Koerber, Stander & Donovick, 1953; Bonicke, 1954; Barry, Conalty, Denneny, Gaffney & Winder, 1954; Lewin & Hirsch, 1955; Kruger-Thiemer, 1955; Albert & Rees, 1955). The breakdown catalysed by haemin has been studied in some detail (Kruger-Thiemer, 1955; Albert & Rees, 1955). The work in the present

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عنوان ژورنال:
  • The Biochemical journal

دوره 73  شماره 

صفحات  -

تاریخ انتشار 1959